The alpha Sarcoglycan Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to SGCA. This antibody recognizes Human, Mouse, and Rat antigen. The alpha Sarcoglycan Antibody has been validated for the following applications: Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta -sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta -sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta -sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy